HMG-1 (Acetyl Lys82) rabbit pAb
- 货号：YK0145
- 应用：WB;ELISA
- 种属：Human;Mouse;Rat
- 简介：
- >>Base excision repair;>>Autophagy - animal;>>Necroptosis;>>Neutrophil extracellular trap formation
- 蛋白名称：
- HMG-1 (Acetyl Lys82)
- 免疫原：
- Synthesized peptide derived from human HMG-1 (Acetyl Lys82)
- 特异性：
- This antibody detects endogenous levels of Human,Mouse,Rat HMG-1 (Acetyl Lys82)
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:1000-2000 ELISA 1:5000-20000
- 纯化工艺：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- High mobility group protein B1 (High mobility group protein 1;HMG-1)
- 背景：
- function:Binds preferentially single-stranded DNA and unwinds double stranded DNA.,similarity:Belongs to the HMGB family.,similarity:Contains 2 HMG box DNA-binding domains.,
- 功能：
- negative regulation of transcription from RNA polymerase II promoter, DNA metabolic process, DNA replication, DNA-dependent DNA replication, DNA ligation, DNA unwinding during replication, DNA repair, base-excision repair, base-excision repair, DNA ligation, DNA recombination, chromatin organization, regulation of transcription, DNA-dependent,regulation of transcription from RNA polymerase II promoter, anti-apoptosis, response to DNA damage stimulus,negative regulation of biosynthetic process, negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process, negative regulation of gene expression, regulation of cell death,negative regulation of transcription, negative regulation of transcriptional preinitiation complex assembly, negative regulation of cellular biosynthetic process, DNA geometric change, DNA duplex unwinding, cellular respo
- 细胞定位：
- Nucleus . Chromosome . Cytoplasm . Secreted . Cell membrane ; Peripheral membrane protein ; Extracellular side . Endosome . Endoplasmic reticulum-Golgi intermediate compartment . In basal state predominantly nuclear. Shuttles between the cytoplasm and the nucleus (PubMed:12231511, PubMed:17114460). Translocates from the nucleus to the cytoplasm upon autophagy stimulation (PubMed:20819940). Release from macrophages in the extracellular milieu requires the activation of NLRC4 or NLRP3 inflammasomes (By similarity). Passively released to the extracellular milieu from necrotic cells by diffusion, involving the fully reduced HGMB1 which subsequently gets oxidized (PubMed:19811284). Also released from apoptotic cells (PubMed:16855214, PubMed:18631454). Active secretion from a variety of immune a
- 组织表达：
- Ubiquitous. Expressed in platelets (PubMed:11154118).
