Acetyl-EPAS-1 (K385) Polyclonal Antibody
- 货号：YK0073
- 应用：WB;ELISA
- 种属：Human;Mouse;Rat
- 简介：
- >>Pathways in cancer;>>Renal cell carcinoma
- 基因名称：
- EPAS1 BHLHE73 HIF2A MOP2 PASD2
- 蛋白名称：
- Acetyl-EPAS-1 (K385)
- 免疫原：
- Synthesized acetyl-peptide of Acetyl-EPAS-1 (K385)
- 特异性：
- Acetyl-EPAS-1 (K385) Polyclonal Antibody detects endogenous levels of Acetyl-EPAS-1 (K385)
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500-2000, ELISA 1:10000-20000
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- endothelial PAS domain protein 1
- 背景：
- endothelial PAS domain protein 1(EPAS1) Homo sapiens This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009],
- 功能：
- disease:Defects in EPAS1 are the cause of erythrocytosis familial type 4 (ECYT4) [MIM:611783]. ECYT4 is an autosomal dominant disorder characterized by increased serum red blood cell mass, elevated hemoglobin concentration and hematocrit, and normal platelet and leukocyte counts.,function:Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300
- 细胞定位：
- Nucleus . Nucleus speckle . Colocalizes with HIF3A in the nucleus and speckles. .
- 组织表达：
- Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells.
