• 靶点：
• HNF-3α/β/γ

• 基因名称：
• FOXA1/FOXA2/FOXA3

• 蛋白名称：
• Hepatocyte nuclear factor 3-alpha/Hepatocyte nuclear factor 3-beta/Hepatocyte nuclear factor 3-gamma

• Human Gene Id：
• 3169

• Human Swiss Prot No：
• P55317

• Mouse Gene Id：
• 15375

• Mouse Swiss Prot No：
• P35582

• Rat Gene Id：
• 25098

• Rat Swiss Prot No：
• P23512

• 免疫原：
• The antiserum was produced against synthesized Acetyl-peptide derived from human FOXA1 around the Acetylation site of Lys265. AA range:231-280

• 特异性：
• Acetyl-HNF-3α/β/γ (K264/253/211) Polyclonal Antibody detects endogenous levels of HNF-3α/β/γ protein only when acetylated at K264/253/211.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• FOXA1;HNF3A;TCF3A;Hepatocyte nuclear factor 3-alpha;HNF-3-alpha;HNF-3A;Forkhead box protein A1;Transcription factor 3A;TCF-3A;FOXA2;HNF3B;TCF3B;Hepatocyte nuclear factor 3-beta;HNF-3-beta;HNF-3B;Forkhead box protein A2;Transcription factor 3B;TCF-3B;FOXA3;HNF3G;TCF3G;Hepatocyte nuclear factor 3-gamma;HNF-3-gamma;HNF-3G;Fork head-related protein FKH H3;Forkhead box protein A3;Transcription factor 3G;TCF-3G

• 实测条带：
• 50kD

• 背景：
• This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008],

• 功能：
• function:Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes.,online information:Hepatocyte nuclear factors entry,similarity:Contains 1 fork-head DNA-binding domain.,

• 细胞定位：
• Nucleus .

• 组织表达：
• Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.

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