CEA (carcinoembryonic antigen)-FC recombinant protein
- 纯度：
- >90% as determined by SDS-PAGE
- 蛋白名称：
- Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e)
- 序列：
- Amino acid:35-314,with FC tag.
- 组成：
- Phosphate-buffered solution
- 储存：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- 其他名称：
- Carcinoembryonic antigen-related cell adhesion molecule 5 ;Carcinoembryonic antigen;CEA;Meconium antigen 100;CD antigen CD66e;CEACAM5;CEA;
- 功能：
- Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).; (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
- 细胞定位：
- Cell membrane ; Lipid-anchor, GPI-anchor . Apical cell membrane . Cell surface . Note=Localized to the apical glycocalyx surface. .
- 组织表达：
- Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
