CD275 (B7-H2, B7-RP1, ICOSL)-FC recombinant protein
- 纯度：
- >90% as determined by SDS-PAGE
- 蛋白名称：
- ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275)
- 序列：
- Amino acid:19-256,with FC tag.
- 组成：
- Phosphate-buffered solution
- 储存：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- 其他名称：
- ICOS ligand ;B7 homolog 2;B7-H2;B7-like protein Gl50;B7-related protein 1;B7RP-1;CD antigen CD275;ICOSLG;B7H2;B7RP1;ICOSL;KIAA0653;
- 功能：
- Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).
- 细胞定位：
- Cell membrane ; Single-pass type I membrane protein .
- 组织表达：
- Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.
