Recombinant Human STAT3 protein ,N- Gst Tag
- 纯度：
- >90% as determined by SDS-PAGE
- 体内研究：
- Please contact with the lab for this information.
- 序列：
- A DNA sequence encoding the human STAT3(Met1~Met770) was fused with the N-terminal Gst Tag
- 组成：
- Supplied as solution form in TBS,pH8.0./ Lyophilized from TBS,pH8.0.
- 稀释：
- Reconstitute in sterile water for a stock solution
- 浓度：
- >90% as determined by SDS-PAGE
- 储存：
- Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
- 细胞定位：
- Cytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
- 组织表达：
- Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in naive CD4(+) T cells as well as T-helper Th17, Th1 and Th2 cells (PubMed:31899195).
