Recombinant Human IL18 protein ,C- His Tag
- 纯度：
- >90% as determined by SDS-PAGE
- 体内研究：
- Please contact with the lab for this information.
- 序列：
- A DNA sequence encoding the human IL18(Tyr37-Asp193) was fused with the C-terminal His Tag
- 组成：
- Supplied as solution form in PBS pH 7.5./ Lyophilized from PBS pH 7.5.
- 稀释：
- Reconstitute in sterile water for a stock solution
- 浓度：
- >90% as determined by SDS-PAGE
- 储存：
- Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
- 细胞定位：
- Cytoplasm . Secreted . The precursor is cytosolic (PubMed:33883744). In response to inflammasome-activating signals, cleaved and secreted (PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). .
