JAK1 protein

    • 货号：YD0055
    • 应用：WB;SDS-PAGE
    • 种属：Human
      • 基因名称：
      • JAK1
      • 蛋白名称：
      • JAK1 protein
      • 序列：
      • Amino acid: 450-618, with his-MBP tag.
      • Human Gene Id：
      • 3716
      • Human Swiss Prot No：
      • P23458
      • Mouse Swiss Prot No：
      • P52332
      • 组成：
      • Liquid in PBS
      • 来源：
      • E.coli
      • 稀释：
      • WB 1:500-2000
      • 浓度：
      • SDS-PAGE >90%
      • 储存：
      • -20°C/6 month,-80°C for long storage
      • 其他名称：
      • Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
      • 背景：
      • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.,domain:The FERM domain mediates interaction with JAKMIP1.,function:Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subcellular location:Wholly intracellular, possibly membrane associated.,subunit:Interacts with IL31RA, JAKMIP1 and SHB.,tissue specificity:Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.,
      • 功能：
      • protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, intracellular signaling cascade,protein kinase cascade, phosphorylation, peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, cytokine-mediated signaling pathway, response to antibiotic,
      • 细胞定位：
      • Endomembrane system; Peripheral membrane protein. Wholly intracellular, possibly membrane associated.
      • 组织表达：
      • Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
      • 产品图片

      相关报价

      • 货号：
      • YD0055
      • 规格：
      • 100μg
      • 价格：
      • ¥2300
      • 货期：
      • 预计发货时间为
        2024-12-29
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