• 基因名称：
• MAPK6

• 蛋白名称：
• ERK3 protein

• 序列：
• Amino acid: 538-721, with his-MBP tag.

• Human Gene Id：
• 5597

• Human Swiss Prot No：
• Q16659

• Mouse Swiss Prot No：
• Q61532

• 组成：
• Liquid in PBS

• 来源：
• E.coli

• 稀释：
• WB 1:500-2000

• 浓度：
• SDS-PAGE >90%

• 储存：
• -20°C/6 month,-80°C for long storage

• 其他名称：
• Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK)

• 背景：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by threonine and tyrosine phosphorylation.,function:Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle.,PTM:Dually phosphorylated on Thr-626 and Tyr-628, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.,

• 功能：
• protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell cycle,phosphorylation,

• 细胞定位：
• Cytoplasm . Nucleus . Translocates to the cytoplasm following interaction with MAPKAPK5. .

• 组织表达：
• Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.

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