ERK2 & 1 protein

    • 货号：YD0027
    • 应用：WB;SDS-PAGE
    • 种属：Human
      • 基因名称：
      • MAPK1/MAPK3
      • 蛋白名称：
      • ERK2 & 1 protein
      • 序列：
      • Amino acid: 146-210, with his-MBP tag.
      • 组成：
      • Liquid in PBS
      • 来源：
      • E.coli
      • 稀释：
      • WB 1:500-2000
      • 浓度：
      • SDS-PAGE >90%
      • 储存：
      • -20°C/6 month,-80°C for long storage
      • 背景：
      • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by tyrosine phosphorylation in response to insulin and NGF.,function:Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).,PTM:Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MORG1 (By similarity). Binds to HIV-1 Nef. This interaction inhibits its kinase activity. Interacts with HSF4 and NISCH.,
      • 功能：
      • protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell cycle,intracellular signaling cascade, small GTPase mediated signal transduction, Ras protein signal transduction,phosphorylation,
      • 细胞定位：
      • Cytoplasm . Nucleus. Membrane, caveola . Cell junction, focal adhesion . Autophosphorylation at Thr-207 promotes nuclear localization (PubMed:19060905). PEA15-binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm (By similarity). .
      • 产品图片

      相关报价

      • 货号：
      • YD0027
      • 规格：
      • 100μg
      • 价格：
      • ¥2300
      • 货期：
      • 预计发货时间为
        2024-12-29
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