• 靶点：
• MMP-7

• 简介：
• >>Wnt signaling pathway;>>Human T-cell leukemia virus 1 infection

• 基因名称：
• MMP7 MPSL1 PUMP1

• 蛋白名称：
• MMP7 (Cleaved-Tyr95)

• Human Gene Id：
• 4316

• Human Swiss Prot No：
• P09237

• Mouse Swiss Prot No：
• Q10738

• Rat Gene Id：
• 25335

• Rat Swiss Prot No：
• P50280

• 免疫原：
• Synthesized peptide derived from human MMP7 (Cleaved-Tyr95)

• 特异性：
• This antibody detects endogenous levels of Human,Mouse,Rat MMP7 (Cleaved-Tyr95, protein was cleaved amino acid sequence between 94-95 )

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Matrilysin (EC 3.4.24.23;Matrin;Matrix metalloproteinase-7;MMP-7;Pump-1 protease;Uterine metalloproteinase)

• 实测条带：
• 19 29kD

• 背景：
• catalytic activity:Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).,cofactor:Binds 2 calcium ions per subunit.,cofactor:Binds 2 zinc ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.,similarity:Belongs to the peptidase M10A family.,

• 功能：
• proteolysis, collagen catabolic process, collagen metabolic process, regulation of cell proliferation, multicellular organismal metabolic process, multicellular organismal catabolic process, multicellular organismal macromolecule metabolic process,

• 细胞定位：
• Secreted, extracellular space, extracellular matrix .

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