• 靶点：
• PPGB

• 简介：
• >>Lysosome;>>Renin-angiotensin system

• 基因名称：
• CTSA PPGB

• 蛋白名称：
• PPGB (20k, Cleaved-Met327)

• Human Gene Id：
• 5476

• Human Swiss Prot No：
• P10619

• Mouse Gene Id：
• 19025

• Mouse Swiss Prot No：
• P16675

• 免疫原：
• Synthesized peptide derived from human PPGB (20k, Cleaved-Met327)

• 特异性：
• This antibody detects endogenous levels of Human,Mouse PPGB (20k, Cleaved-Met327, protein was cleaved amino acid sequence between 326-327 )

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Lysosomal protective protein (EC 3.4.16.5;Carboxypeptidase C;Carboxypeptidase L;Cathepsin A;Protective protein cathepsin A;PPCA;Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain;Lysosomal protective protein 20 kDa chain]

• 实测条带：
• 20 52kD

• 背景：
• catalytic activity:Release of a C-terminal amino acid with broad specificity.,disease:Defects in CTSA are the cause of galactosialidosis [MIM:256540]. It is an autosomal recessive disease.,function:Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.,similarity:Belongs to the peptidase S10 family.,subunit:Heterodimer of a 32 kDa chain and a 20 kDa chain; disulfide-linked.,

• 功能：
• proteolysis, intracellular protein transport, protein localization, protein transport, cellular protein localization,establishment of protein localization, intracellular transport, cellular macromolecule localization,

• 细胞定位：
• Lysosome.

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