• 靶点：
• ITGAV

• 简介：
• >>Phagosome;>>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Cell adhesion molecules;>>Regulation of actin cytoskeleton;>>Thyroid hormone signaling pathway;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Pathways in cancer;>>Proteoglycans in cancer;>>Small cell lung cancer;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy;>>Fluid shear stress and atherosclerosis

• 基因名称：
• ITGAV MSK8 VNRA

• 蛋白名称：
• ITGAV (light chain, Cleaved-Asp891)

• Human Gene Id：
• 3685

• Human Swiss Prot No：
• P06756

• Mouse Gene Id：
• 16410

• Mouse Swiss Prot No：
• P43406

• 免疫原：
• Synthesized peptide derived from human ITGAV (light chain, Cleaved-Asp891)

• 特异性：
• This antibody detects endogenous levels of Human,Mouse ITGAV (light chain, Cleaved-Asp891, protein was cleaved amino acid sequence between 890-891 )

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Integrin alpha-V (Vitronectin receptor subunit alpha;CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain;Integrin alpha-V light chain]

• 实测条带：
• 17 110kD

• 背景：
• integrin subunit alpha V(ITGAV) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015],

• 功能：
• function:The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus (By similarity). Alpha-V/beta-6 binds to coxsack

• 细胞定位：
• Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion .

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