FA9 (light chain, Cleaved-Tyr47) rabbit pAb

  • 货号：YC0127
  • 应用：WB;ELISA
  • 种属：Human;Mouse;Rat
    • 靶点：
    • Factor IX
    • 简介：
    • >>Complement and coagulation cascades
    • 基因名称：
    • F9 Factor IX
    • 蛋白名称：
    • FA9 (light chain, Cleaved-Tyr47)
    • Human Gene Id：
    • 2158
    • Human Swiss Prot No：
    • P00740
    • Mouse Swiss Prot No：
    • P16294
    • 免疫原：
    • Synthesized peptide derived from human FA9 (light chain, Cleaved-Tyr47)
    • 特异性：
    • This antibody detects endogenous levels of Human,Mouse,Rat FA9 (light chain, Cleaved-Tyr47, protein was cleaved amino acid sequence between 46-47 )
    • 组成：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源：
    • Polyclonal, Rabbit,IgG
    • 稀释：
    • WB 1:1000-2000 ELISA 1:5000-20000
    • 纯化工艺：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • 浓度：
    • 1 mg/ml
    • 储存：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 其他名称：
    • Coagulation factor IX (EC 3.4.21.22;Christmas factor;Plasma thromboplastin component;PTC) [Cleaved into: Coagulation factor IXa light chain;Coagulation factor IXa heavy chain]
    • 实测条带：
    • 16 45kD
    • 背景：
    • This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Sep 2015],
    • 功能：
    • catalytic activity:Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.,disease:Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.,disease:Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.,domain:Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.,function:Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.,miscellaneous
    • 细胞定位：
    • Secreted .
    • 组织表达：
    • Detected in blood plasma (at protein level) (PubMed:3857619, PubMed:8295821, PubMed:2592373, PubMed:9169594, PubMed:19846852). Synthesized primarily in the liver and secreted in plasma.

    相关报价

    • 货号：
    • YC0127
    • 规格：
    • 40μL / 100μL / 200μL
    • 价格：
    • ¥960 / 2300 / 3780
    • 货期：
    • 预计发货时间为
      2024-07-25
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