CATB (Cleaved-Asn126) rabbit pAb
- 货号：YC0121
- 应用：WB;ELISA
- 种属：Human;Rat;Mouse;
- 简介：
- >>Autophagy - animal;>>Lysosome;>>Apoptosis;>>Antigen processing and presentation;>>NOD-like receptor signaling pathway;>>Renin secretion
- 蛋白名称：
- CATB (Cleaved-Asn126)
- 免疫原：
- Synthesized peptide derived from human CATB (Cleaved-Asn126)
- 特异性：
- This antibody detects endogenous levels of Human CATB (Cleaved-Asn126, protein was cleaved amino acid sequence between 126-127 )
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:1000-2000 ELISA 1:5000-20000
- 纯化工艺：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Cathepsin B (EC 3.4.22.1;APP secretase;APPS;Cathepsin B1) [Cleaved into: Cathepsin B light chain;Cathepsin B heavy chain]
- 背景：
- catalytic activity:Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.,function:Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.,similarity:Belongs to the peptidase C1 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.,
- 功能：
- proteolysis, response to wounding, regulation of cell death, regulation of apoptosis, regulation of programmed cell death,
- 细胞定位：
- Lysosome . Melanosome . Secreted, extracellular space . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity). .
- 组织表达：
- Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum.
