• 靶点：
• MMP-15

• 简介：
• >>Parathyroid hormone synthesis, secretion and action

• 基因名称：
• MMP15

• 蛋白名称：
• Matrix metalloproteinase-15

• Human Gene Id：
• 4324

• Human Swiss Prot No：
• P51511

• Mouse Swiss Prot No：
• O54732

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human MMP15. AA range:113-162

• 特异性：
• Cleaved-MMP-15 (Y132) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-15 protein resulting from cleavage adjacent to Y132.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MMP15;Matrix metalloproteinase-15;MMP-15;Membrane-type matrix metalloproteinase 2;MT-MMP 2;MTMMP2;Membrane-type-2 matrix metalloproteinase;MT2-MMP;MT2MMP;SMCP-2

• 实测条带：
• 61kD

• 背景：
• This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016],

• 功能：
• cofactor:Binds 1 zinc ion per subunit.,cofactor:Calcium.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.,

• 细胞定位：
• Membrane ; Single-pass type I membrane protein ; Extracellular side .

• 组织表达：
• Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.

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