Cleaved-Cathepsin D LC (G65) Polyclonal Antibody

    • 货号：YC0038
    • 应用：WB;ELISA
    • 种属：Human;Monkey
      • 靶点：
      • Cathepsin D
      • 简介：
      • >>Sphingolipid signaling pathway;>>Autophagy - animal;>>Lysosome;>>Apoptosis;>>Estrogen signaling pathway;>>Tuberculosis;>>Diabetic cardiomyopathy
      • 基因名称：
      • CTSD
      • 蛋白名称：
      • Cathepsin D
      • Human Gene Id：
      • 1509
      • Human Swiss Prot No：
      • P07339
      • Mouse Swiss Prot No：
      • P18242
      • 免疫原：
      • The antiserum was produced against synthesized peptide derived from human CATD. AA range:46-95
      • 特异性：
      • Cleaved-Cathepsin D LC (G65) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin D LC protein resulting from cleavage adjacent to G65.
      • 组成：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源：
      • Polyclonal, Rabbit,IgG
      • 稀释：
      • WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
      • 纯化工艺：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度：
      • 1 mg/ml
      • 储存：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称：
      • CTSD;CPSD;Cathepsin D
      • 实测条带：
      • 17kD
      • 背景：
      • This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015],
      • 功能：
      • catalytic activity:Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.,disease:Defects in CTSD are the cause of neuronal ceroid lipofuscinosis 10 (CLN10) [MIM:610127]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. The neuronal ceroid lipofuscinosis are a group of progressive neurodegenerative diseases in children and in adults, characterized by visual and mental decline, motor disturbance, epilepsy and behavioral changes.,function:Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.,polymorphism:The Val-58 allele is significantly overrepresented in demented patients (11.8%) compared with non-demented controls (4.9%). Carriers of the Val-58 allele have a 3.1-fold increased risk for de
      • 细胞定位：
      • Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). .
      • 组织表达：
      • Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).
      • 产品图片
      • Western Blot analysis of various cells using Cleaved-Cathepsin D LC (G65) Polyclonal Antibody

      相关报价

      • 货号：
      • YC0038
      • 规格：
      • 40μL / 100μL / 200μL
      • 价格：
      • ¥960 / 2300 / 3780
      • 货期：
      • 预计发货时间为
        2024-07-17
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