HLA-DRA (PN0161) Nb-FC recombinant antibody
- 货号：YA0603
- 应用：ELISA
- 种属：Human
- 蛋白名称：
- HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA)
- 免疫原：
- Purified recombinant Human HLA-DRA
- 特异性：
- This recombinant monoclonal antibody can detects endogenous levels of HLA-DRA protein.
- 组成：
- Phosphate-buffered solution
- 来源：
- Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 浓度：
- Please check the information on the tube
- 储存：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- 其他名称：
- DASS-397D15.1 antibody;DR alpha chain antibody;DR alpha chain precursor antibody;DRA_HUMAN antibody;DRB1 antibody;DRB4 antibody;FLJ51114 antibody;Histocompatibility antigen HLA DR alpha antibody;Histocompatibility antigen HLA-DR alpha antibody;HLA class II histocompatibility antigen antibody;HLA class II histocompatibility antigen DR alpha chain antibody;HLA DR1B antibody;HLA DR3B antibody;HLA DRA antibody;HLA DRA1 antibody;HLA DRB1 antibody;HLA DRB3 antibody;HLA DRB4 antibody;HLA DRB5 antibody;HLA-DR histocompatibility type antibody;HLA-DRA antibody;HLADR4B antibody;HLADRA1 antibody;HLADRB antibody;Major histocompatibility complex class II DR alpha antibody;Major histocompatibility complex class II DR beta 1 antibody;Major histocompatibility complex class II DR beta 3 antibody;Major histocompatibility complex class II DR beta 4 antibody;Major histocompatibility complex class II DR beta 5 antibody;MGC117330 antibody;MHC cell surface glycoprotein antibody;MHC class II antigen DRA antib
- 背景：
- HLA-DRA is one of the HLA class II alpha chain paralogues.This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]
- 功能：
- disease:Genetic variations in HLA-DRA are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.,polymorphism:The following alleles of DRA are known: DRA*0101 and DRA*0102. The sequence shown is that of DRA*0101.,similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Heterodimer of an alpha chain and a beta chain.,
- 细胞定位：
- Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . Late endosome membrane ; Single-pass type I membrane protein . Lysosome membrane ; Single-pass type I membrane protein . Autolysosome membrane ; Single-pass type I membrane protein. The MHCII complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation (PubMed:9075930, PubMed:18305173). Component of immunological synapses at the interface between T cell and APC (PubMed:15322540, PubMed:29884618). .
- 组织表达：
- Expressed in professional APCs: macrophages, dendritic cells and B cells (at protein level) (PubMed:31495665, PubMed:1532254, PubMed:23783831). Expressed in thymic epithelial cells (at protein level) (PubMed:23783831).
