CD96 (PN0239) Nb-FC recombinant antibody
- 货号：YA0577
- 应用：ELISA
- 种属：Human
- 蛋白名称：
- T-cell surface protein tactile (Cell surface antigen CD96) (T cell-activated increased late expression protein) (CD antigen CD96)
- 免疫原：
- Purified recombinant Human CD96
- 特异性：
- This recombinant monoclonal antibody can detects endogenous levels of CD96 protein.
- 组成：
- Phosphate-buffered solution
- 来源：
- Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 浓度：
- Please check the information on the tube
- 储存：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- 其他名称：
- CD96;T-cell surface protein tactile;Cell surface antigen CD96;T cell-activated increased late expression protein;CD96;CD96 nanobody;
- 背景：
- The protein encoded byThis gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
- 功能：
- developmental stage:Expressed at low levels on peripheral T-cells and is strongly up-regulated after activation, peaking 6 to 9 days after the activating stimulus.,disease:A chromosomal aberration involving CD96 is associated with C syndrome [MIM:211750]. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint.,disease:Defects in CD96 are a cause of C syndrome [MIM:211750]; also called Opitz trigonocephaly syndrome. This syndrome is characterized by trigonocephaly and associated anomalies, such as unusual facies, wide alveolar ridges, multiple buccal frenula, limb defects, visceral anomalies, redundant skin, psy
- 细胞定位：
- Membrane; Single-pass type I membrane protein.
- 组织表达：
- Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
