CD94 (PN0248) Nb-FC recombinant antibody
- 货号：YA0571
- 应用：ELISA;FCM
- 种属：Human
- 蛋白名称：
- Natural killer cells antigen CD94 (KP43) (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (CD antigen CD94)
- 免疫原：
- Purified recombinant Human CD94
- 特异性：
- This recombinant monoclonal antibody can detects endogenous levels of CD94 protein.
- 组成：
- Phosphate-buffered solution
- 来源：
- Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
- 稀释：
- ELISA 1:5000-100000 FCM 1-2μg/Test
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 浓度：
- Please check the information on the tube
- 储存：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- 其他名称：
- KLRD1;CD94;Natural killer cells antigen CD94;KP43;Killer cell lectin-like receptor subfamily D member 1;NK cell receptor;CD antigen CD94;CD94 nanobody;
- 背景：
- Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found forThis gene. [provided by RefSeq, Jul 2008]
- 功能：
- Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.,online information:CD94,similarity:Contains 1 C-type lectin domain.,subunit:Can form disulfide-bonded heterodimer with NKG2 family members.,tissue specificity:Natural killer cells.,
- 细胞定位：
- Cell membrane ; Single-pass type II membrane protein .
- 组织表达：
- Expressed in NK cell subsets (at protein level) (PubMed:21825173, PubMed:94322, PubMed:948526). Expressed in memory/effector CD8-positive alpha-beta T cell subsets (at protein level) (PubMed:12387742, PubMed:2952657). Expressed in melanoma-specific cytotoxic T cell clones (at protein level) (PubMed:948526). Expressed in terminally differentiated cytotoxic gamma-delta T cells (at protein level) (PubMed:2952657). KLRD1-KLRC1 and KLRD1-KLRC2 are differentially expressed in NK and T cell populations, with only minor subsets expressing both receptor complexes (at protein level) (PubMed:2952657).
