CD62P (PN0135) Nb-FC recombinant antibody
- 货号：YA0433
- 应用：ELISA
- 种属：Human
- 蛋白名称：
- P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membra
- 免疫原：
- Purified recombinant Human CD62P
- 特异性：
- This recombinant monoclonal antibody can detects endogenous levels of CD62P protein.
- 组成：
- Phosphate-buffered solution
- 来源：
- Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 浓度：
- Please check the information on the tube
- 储存：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- 其他名称：
- CD62;GRMP;PSEL;CD62P;GMP140;LECAM3;PADGEM;CD62P nanobody;
- 背景：
- CD62P is a 140 kD type I transmembrane glycoprotein also known as P-selectin, platelet activation-dependent granule membrane protein (PADGEM), and GMP-140. It is expressed on activated platelets, megakaryocytes, and endothelial cells. CD62P is primarily stored in secretory α-granules in platelets and Weibel-Palade bodies in endothelial cells, and is rapidly relocated to the plasma membrane upon activation. The ligands for CD62P are CD162 and CD24. A primary function of CD62P is cell adhesion during neutrophil rolling, and platelet-neutrophil and platelet-monocyte interactions.
- 功能：
- Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.
- 细胞定位：
- Cell membrane ; Single-pass type I membrane protein .
- 组织表达：
- Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
