CD62L (PN0043) Nb-FC recombinant antibody

  • 货号:YA0428
  • 应用:ELISA;FCM
  • 种属:Human
    • 靶点:
    • CD62L
    • 基因名称:
    • SELL LNHR LYAM1
    • 蛋白名称:
    • L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing re
    • Human Gene Id:
    • 6402
    • Human Swiss Prot No:
    • P14151
    • 免疫原:
    • Purified recombinant Human CD62L
    • 特异性:
    • This recombinant monoclonal antibody can detects endogenous levels of CD62L protein.
    • 组成:
    • Phosphate-buffered solution
    • 来源:
    • Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
    • 稀释:
    • ELISA 1:5000-100000 FCM 1-2μg/Test
    • 纯化工艺:
    • Recombinant Expression and Affinity purified
    • 浓度:
    • Please check the information on the tube
    • 储存:
    • -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
    • 其他名称:
    • TQ1;LAM1;LEU8;LNHR;LSEL;CD62L;LYAM1;PLNHR;LECAM1;L-selectin;LECAM-1;SELL;LAM-1;TQ-1;MEL-14;CD62L nanobody;
    • 背景:
    • CD62L is a 74-95 kD single chain type I glycoprotein referred to as L-selectin or LECAM-1. It is expressed on most peripheral blood B cells, subsets of T and NK cells, monocytes, granulocytes, and certain hematopoietic malignant cells. CD62L binds to carbohydrates present on certain glycoforms of CD34, glycam-1, and MAdCAM-1 and with a low affinity to anionic oligosaccharide sequences related to sialylated Lewis X (sLex, CD15s) through its C-type lectin domain. CD62L is important for the homing of naïve lymphocytes to high endothelial venules in peripheral lymph nodes and Peyer's patches. It also plays a role in leukocyte rolling on activated endothelial cells.
    • 功能:
    • Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641).Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).
    • 细胞定位:
    • Cell membrane ; Single-pass type I membrane protein .
    • 组织表达:
    • Expressed in B-cell lines and T-lymphocytes.