• 靶点：
• CD54

• 基因名称：
• ICAM1

• 蛋白名称：
• Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)

• Human Gene Id：
• 3383

• Human Swiss Prot No：
• P05362

• 免疫原：
• Purified recombinant Human CD54

• 特异性：
• This recombinant monoclonal antibody can detects endogenous levels of CD54 protein.

• 组成：
• Phosphate-buffered solution

• 来源：
• Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell

• 稀释：
• ELISA 1:5000-100000

• 纯化工艺：
• Recombinant Expression and Affinity purified

• 浓度：
• Please check the information on the tube

• 储存：
• -15°C to -25°C/1 year(Avoid freeze / thaw cycles)

• 其他名称：
• Antigen identified by monoclonal antibody BB2 antibody;BB 2 antibody;BB2 antibody;CD 54 antibody;CD_antigen=CD54 antibody;CD54 antibody;Cell surface glycoprotein P3.58 antibody;Human rhinovirus receptor antibody;ICAM 1 antibody;ICAM-1 antibody;ICAM1 antibody;ICAM1_HUMAN antibody;intercellular adhesion molecule 1 (CD54) antibody;intercellular adhesion molecule 1 (CD54);human rhinovirus receptor antibody;Intercellular adhesion molecule 1 antibody;Major group rhinovirus receptor antibody;MALA 2 antibody;MALA2 antibody;MyD 10 antibody;MyD10 antibody;P3.58 antibody;Surface antigen of activated B cells antibody;Surface antigen of activated B cells;BB2 antibody;CD54 nanobody;

• 背景：
• This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

• 功能：
• ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.,online information:ICAM-1,online information:Icosahedral capsid structure,online information:Intercellular adhesion molecule entry,polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.,PTM:Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregatio

• 细胞定位：
• Membrane; Single-pass type I membrane protein.

• 组织表达：
• Blood,Kidney,Liver,Melanoma,Plasma

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