CD371 (PN0385) Nb-FC recombinant antibody
- 货号：YA0336
- 应用：ELISA
- 种属：Human
- 基因名称：
- CLEC12A CLL1 DCAL2 MICL
- 蛋白名称：
- C-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Dendritic cell-associated lectin 2) (DCAL-2) (Myeloid inhibitory C-type lectin-like receptor) (MICL) (CD antigen CD371)
- 免疫原：
- Purified recombinant Human CD371
- 特异性：
- This recombinant monoclonal antibody can detects endogenous levels of CD371 protein.
- 组成：
- Phosphate-buffered solution
- 来源：
- Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 浓度：
- Please check the information on the tube
- 储存：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- 其他名称：
- CLL1;MICL;CLL-1;DCAL-2;C-type lectin domain family 12 member A;CD371;CD371 nanobody;
- 背景：
- CD371 (CLEC12A), also known as DCAL-2, MICL or CLL-1, is a 30 kD type II transmembrane protein with extracellular C-type lectin domains, belonging to the C-type lectin family. It is expressed on monocytes, granulocytes, NK cells, and basophils. Its cytoplasmic ITIM motif modulates signaling cascades and is involved in phosphorylation of tyrosine residues in MAP kinases.
- 功能：
- Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
- 细胞定位：
- Cell membrane ; Single-pass type II membrane protein . Ligand binding leads to internalization.
- 组织表达：
- Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
