CD314/NKG2D (PN0145) Nb-FC recombinant antibody
- 货号：YA0282
- 应用：ELISA
- 种属：Human
- 基因名称：
- KLRK1 D12S2489E NKG2D
- 蛋白名称：
- NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)
- 免疫原：
- Purified recombinant Human CD314
- 特异性：
- This recombinant monoclonal antibody can detects endogenous levels of CD314/NKG2D protein.
- 组成：
- Phosphate-buffered solution
- 来源：
- Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 浓度：
- Please check the information on the tube
- 储存：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- 其他名称：
- NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1;NK cell receptor D;NKG2-D-activating NK receptor;CD antigen CD314);CD314 nanobody;NKG2D nanobody;
- 背景：
- Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells.This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of
- 功能：
- alternative products:A number of isoforms are produced,Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.,miscellaneous:Structurally distinct families of ligands for mouse and human NKG2D receptors have been characterized. They might be orthologs.,online information:NKG-2D,similarity:Contains 1 C-type lectin domain.,subunit:Homodimer. Interacts with DAP10. The interaction with DAP10 is required for NKG2D cell surface expression.,tissue specificity:Natural killer cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Also detected in gamma-delta cells and CD8+ alpha-beta T-cells. Expressed in interferon-producing killer dendritic cells (IKDCs).,
- 细胞定位：
- Cell membrane ; Single-pass type II membrane protein . Colocalized with HCST on the cell surface.
- 组织表达：
- Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).
