CD279/PD1 (PN0619) Nb-FC recombinant antibody
- 货号：YA0257
- 应用：ELISA
- 种属：Human
- 蛋白名称：
- Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
- 免疫原：
- Purified recombinant Human PD1
- 特异性：
- This recombinant monoclonal antibody can detects endogenous levels of CD279/PD1 protein.
- 组成：
- Phosphate-buffered solution
- 来源：
- Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 浓度：
- Please check the information on the tube
- 储存：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- 其他名称：
- CD279 antibody;CD279 antigen antibody;hPD 1 antibody;hPD l antibody;hPD-1 antibody;hSLE1 antibody;PD 1 antibody;PD-1 antibody;PD1 antibody;PDCD 1 antibody;PDCD1 antibody;PDCD1_HUMAN antibody;Programmed cell death 1 antibody;Programmed cell death 1 protein antibody;Programmed cell death protein 1 antibody;Protein PD 1 antibody;Protein PD-1 antibody;SLEB2 antibody;Systemic lupus erythematosus susceptibility 2 antibody;CD279 nanobody;PD1 nanobody;
- 背景：
- This gene encodes a cell surface membrane protein of the immunoglobulin superfamily.This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression ofThis gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient forThis gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest thatThis gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
- 功能：
- developmental stage:Induced at programmed cell death.,disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,Possible cell death inducer, in association with other factors.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Monomer.,
- 细胞定位：
- Cell membrane ; Single-pass type I membrane protein.
- 组织表达：
- Placenta,Pooled tissue,Uterine cervix
