• 靶点：
• CD26

• 基因名称：
• DPP4 ADCP2 CD26

• 蛋白名称：
• Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved

• Human Gene Id：
• 1803

• Human Swiss Prot No：
• P27487

• 免疫原：
• Purified recombinant Human CD26

• 特异性：
• This recombinant monoclonal antibody can detects endogenous levels of CD26 protein.

• 组成：
• Phosphate-buffered solution

• 来源：
• Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell

• 稀释：
• ELISA 1:5000-100000

• 纯化工艺：
• Recombinant Expression and Affinity purified

• 浓度：
• Please check the information on the tube

• 储存：
• -15°C to -25°C/1 year(Avoid freeze / thaw cycles)

• 其他名称：
• DPP4;ADCP2;CD26;Dipeptidyl peptidase 4;ADABP;Adenosine deaminase complexing protein 2;ADCP-2;Dipeptidyl peptidase IV;DPP IV;T-cell activation antigen CD26;TP103;CD26;CD26 nanobody;

• 背景：
• The protein encoded byThis gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]

• 功能：
• catalytic activity:Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.,Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Plays a role in T-cell activation.,online information:Dipeptidyl peptidase-4 entry,PTM:The soluble form (SDPP) derives from the membrane form (MDPP) by proteolytic processing.,similarity:Belongs to the peptidase S9B family. DPPIV subfamily.,subunit:Homodimer or heterodimer with Seprase (FAP).,tissue specificity:Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.,

• 细胞定位：
• [Dipeptidyl peptidase 4 soluble form]: Secreted . Detected in the serum and the seminal fluid. .; Cell membrane ; Single-pass type II membrane protein. Apical cell membrane ; Single-pass type II membrane protein. Cell projection, invadopodium membrane ; Single-pass type II membrane protein. Cell projection, lamellipodium membrane ; Single-pass type II membrane protein. Cell junction . Membrane raft . Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids (PubMed:11773049). Redistributed to membrane rafts in T-cell in an interleukin-12-dependent activation (PubMed:12676959). Its interaction with CAV1 is necessary for its translocation to membrane rafts (PubMed:17287217). Coloca

• 组织表达：
• Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.

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