CD162 (PN0284) Nb-FC recombinant antibody
- 货号：YA0124
- 应用：ELISA
- 种属：Human
- 蛋白名称：
- P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162)
- 免疫原：
- Purified recombinant Human CD162
- 特异性：
- This recombinant monoclonal antibody can detects endogenous levels of CD162 protein.
- 组成：
- Phosphate-buffered solution
- 来源：
- Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 浓度：
- Please check the information on the tube
- 储存：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- 其他名称：
- CLA;CD162;PSGL1;PSGL-1;PSGL-1;p-selectin glycoprotein ligand-1;CD 162 antibody;CD162 antibody;CD162 antigen antibody;CLA antibody;Cutaneous lymphocyte associated associated antigen antibody;P selectin glycoprotein ligand 1 antibody;P selectin glycoprotein ligand 1 precursor antibody;P-selectin glycoprotein ligand 1 antibody;PSGL 1 antibody;PSGL-1 antibody;PSGL1 antibody;Selectin P ligand antibody;SELPL_HUMAN antibody;SELPLG antibody;
- 背景：
- CD162, also known as p-selectin glycoprotein ligand-1 (PSGL-1), is a 120 - 220 kD, mucin-like type I transmembrane glycoprotein. CD162 binds to CD62P (P-Selectin), CD62E (E-Selectin) and CD62L (L-Selectin). The interactions between P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) mediate the earliest "rolling" of leukocytes on the lumenal surface of activated endothelium, and the interaction between leukocytes and activated platelets or other leukocytes found at sites of inflammation. CD162 is expressed on neutrophils, monocytes, and most lymphocytes including NK and T cells but PSGL-1 stains B cells at significantly lower levels than other cell types.
- 功能：
- A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
- 细胞定位：
- Membrane; Single-pass type I membrane protein.
- 组织表达：
- Expressed on neutrophils, monocytes and most lymphocytes.
