CD161 (PN0046) Nb-FC recombinant antibody
- 货号：YA0123
- 应用：ELISA
- 种属：Human
- 基因名称：
- KLRB1 CLEC5B NKRP1A
- 蛋白名称：
- Killer cell lectin-like receptor subfamily B member 1 (C-type lectin domain family 5 member B) (HNKR-P1a) (NKR-P1A) (Natural killer cell surface protein P1A) (CD antigen CD161)
- 免疫原：
- Purified recombinant Human CD161
- 特异性：
- This recombinant monoclonal antibody can detects endogenous levels of CD161 protein.
- 组成：
- Phosphate-buffered solution
- 来源：
- Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 浓度：
- Please check the information on the tube
- 储存：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- 其他名称：
- KLRB1;CLEC5B;NKRP1A;Killer cell lectin-like receptor subfamily B member 1;C-type lectin domain family 5 member B;HNKR-P1a;NKR-P1A;Natural killer cell surface protein P1A;CD161
- 背景：
- Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
- 功能：
- Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.,induction:By IL12 in NK cells.,online information:NKRP1,PTM:N-glycosylated. Contains sialic acid residues.,similarity:Contains 1 C-type lectin domain.,subunit:Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1.,tissue specificity:Expressed in a subset of NK cells predomin
- 细胞定位：
- Membrane ; Single-pass type II membrane protein .
- 组织表达：
- Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
