CD16 (PN0531) Nb-FC recombinant antibody
- 货号：YA0115
- 应用：ELISA
- 种属：Human
- 基因名称：
- FCGR3A CD16A FCG3 FCGR3 IGFR3
- 蛋白名称：
- Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (F
- 免疫原：
- Purified recombinant Human CD16
- 特异性：
- This recombinant monoclonal antibody can detects endogenous levels of CD16 protein.
- 组成：
- Phosphate-buffered solution
- 来源：
- Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 浓度：
- Please check the information on the tube
- 储存：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- 其他名称：
- CD 16 antibody;CD 16a antibody;CD16 antibody;CD16a antibody;CD16a antigen antibody;CD16B antibody;CD16b antigen antibody;Fc fragment of IgG antibody;Fc fragment of IgG low affinity IIIa receptor (CD16) antibody;Fc fragment of IgG low affinity IIIa receptor antibody;Fc fragment of IgG receptor IIIa antibody;Fc fragment of IgG;low affinity III;receptor (CD16) antibody;Fc fragment of IgG;low affinity III;receptor for (CD16) antibody;Fc fragment of IgG;low affinity IIIa;receptor (CD16) antibody;Fc fragment of IgG;low affinity IIIa;receptor (CD16a) antibody;Fc fragment of IgG;low affinity IIIa;receptor for antibody;Fc fragment of IgG;low affinity IIIb;receptor (CD16b) antibody;Fc fragment of IgG;low affinity IIIb;receptor for (CD16) antibody;Fc gamma R3 antibody;Fc gamma receptor III 2 (CD 16) antibody;Fc gamma receptor III A antibody;Fc gamma receptor IIIA antibody;Fc gamma receptor IIIb (CD 16) antibody;Fc gamma RIII alpha antibody;Fc gamma RIII antibody;Fc gamma RIII beta antibody;Fc ga
- 背景：
- This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses.This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded byThis gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations inThis gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found forThis gene. [provided by RefSeq,
- 功能：
- Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.,miscellaneous:Encoded by one of two nearly indentical genes: FCGR3A (Shown here) and FCGR3B which are expressed in a tissue-specific manner. The Phe-203 in III-A determines the transmembrane domains whereas the Ser-203 in III-B determines the GPI-anchoring.,online information:FCGR3A mutation db,polymorphism:Isoform Val-157 shows a higher binding capacity of IgG1, IgG3 and IgG4 compared with isoform Phe-157. Alleles Leu-66 and Phe-157, and alleles His-66 / Arg-66 and Val-157 are in linkage desequilibrium.,PTM:Glycosylated. Contains high mannose- and complex-type oligosaccharides.,PTM:The soluble form is produced by a proteolytic cleavage.,similarity:Contains 2 Ig-like C2-type (imm
- 细胞定位：
- Cell membrane ; Single-pass type I membrane protein . Secreted . Exists also as a soluble receptor. .
- 组织表达：
- Expressed in natural killer cells (at protein level) (PubMed:2526846). Expressed in a subset of circulating monocytes (at protein level) (PubMed:2767158).
