CD142 (PN0275) Nb-FC recombinant antibody
- 货号：YA0101
- 应用：ELISA
- 种属：Human
- 蛋白名称：
- Tissue factor (TF) (Coagulation factor III) (Thromboplastin) (CD antigen CD142)
- 免疫原：
- Purified recombinant Human CD142
- 特异性：
- This recombinant monoclonal antibody can detects endogenous levels of CD142 protein.
- 组成：
- Phosphate-buffered solution
- 来源：
- Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 浓度：
- Please check the information on the tube
- 储存：
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- 其他名称：
- Coagulation Factor III;Tissue Factor (TF);Thromboplastin;platelet tissue factor;factor III;factor 3;F3;F-3;TFA
- 背景：
- CD142, also known as Tissue Factor (TF), Coagulation Factor III, and Thromboplastin, is a 45 kD type I transmembrane glycoprotein. It is expressed on the surface of a variety of cells that are physically separated from the circulating blood which include smooth muscle cells, fibroblasts, keratinocytes, glomerular epithelial cells (cytoplasmic inclusions), astrocytes, myocardium, liver stromal cells, pancreas cells, and is also expressed on activated monocytes and stimulated endothelial cells. CD142 is a high-affinity receptor for coagulation factor VII and initiates the extrinsic pathway of blood coagulation. CD142 also plays an important role in a variety of diseases such as sepsis, atherosclerosis, and cancer.
- 功能：
- Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
- 细胞定位：
- [Isoform 1]: Membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .
- 组织表达：
- Lung, placenta and pancreas.
