UK-371804 HCl

    • 货号:MC1356
      • CasNo:
      • 256476-36-5
      • 分子式:
      • C14H16ClN5O4S.HCl
      • 纯度:
      • >98%
      • 靶点:
      • Ser/Thr Protease
      • IC50:
      • Ki: 10 nM (uPA)[1]
      • 体外研究:
      • UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 μM). UK-371804 has its excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin)[1].
      • 体内研究:
      • In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM[1].
      • 简介:
      • UK-371804 is a potent and selective uPA inhibitor with excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). Ki: 10 nM (uPA)[1]
      • 特异性:
      • Target: Ser/Thr Protease. Fields: UK-371804 is a potent and selective uPA inhibitor with excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin)
      • 稀释:
      • Ki: 10 nM (uPA)[1]
      • 浓度:
      • >98%
      • 储存:
      • 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
      • 其他名称:
      • UK371804,UK 371804
      • 分子量:
      • 422.29
      • 产品图片