XMD8-87

    • 货号:MC1275
      • CasNo:
      • 1234480-46-6
      • 分子式:
      • C24H27N7O2
      • 纯度:
      • >98%
      • 靶点:
      • Tyrosinase
      • IC50:
      • IC50: 38 nM (TNK2, D163E mutation), 113 nM (TNK2, R806Q mutation)[1]
      • 体外研究:
      • XMD8-87 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD8-87 has IC50s of 38 nM and 113 nM for the D163E and R806Q mutations. The effects of XMD8-87 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD8-87[1].
      • 体内研究:
      • 简介:
      • XMD8-87 is a novel TNK2 inhibitor. IC50: 38 nM (TNK2, D163E mutation), 113 nM (TNK2, R806Q mutation)[1]
      • 特异性:
      • Target: Tyrosinase. Fields: XMD8-87 is a novel TNK2 inhibitor. IC50: 38 nM (TNK2, D163E mutation), 113 nM (TNK2, R806Q mutation)[1]
      • 稀释:
      • IC50: 38 nM (TNK2, D163E mutation), 113 nM (TNK2, R806Q mutation)[1]
      • 浓度:
      • >98%
      • 储存:
      • 4 Degree for 1 year, -20 degree for more than 2 years
      • 其他名称:
      • XMD-8-87,XMD8 87,XMD 8 87
      • 分子量:
      • 445.22
      • 产品图片