Human Thrombomodulin ELISA Kit
- 货号：KE1252
- 应用：ELISA
- 种属：Human
- 特异性：
- Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
- 其他名称：
- THBD;THRM;Thrombomodulin;TM;Fetomodulin;CD antigen CD141
- 背景：
- disease:Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THR-THBDD) [MIM:188040]. THR-THBDD is a hemostatic disorder characterized by a tendency to thrombosis.,function:Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.,online information:Thrombomodulin,online information:Thrombomodulin entry,PTM:N-glycosylated.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 6 EGF-like domains.,tissue specificity:Endothelial cells are unique in synthesizing thrombomodulin.,
- 功能：
- response to molecule of bacterial origin, female pregnancy, blood coagulation, hemostasis, response to radiation,response to wounding, response to bacterium, response to abiotic stimulus, response to organic substance, response to X-ray, response to ionizing radiation, response to lipopolysaccharide, wound healing, coagulation, regulation of body fluid levels, response to cAMP,
- 细胞定位：
- Membrane; Single-pass type I membrane protein.
- 组织表达：
- Endothelial cells are unique in synthesizing thrombomodulin.
- The Human Thrombomodulin ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human Thrombomodulin proteins within the range of 32-2000 pg/ml.
