Human Pro-Cathepsin B ELISA Kit
- 货号：KE1242
- 应用：ELISA
- 种属：Human
- 特异性：
- Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
- 其他名称：
- CTSB;CPSB;Cathepsin B;APP secretase;APPS;Cathepsin B1
- 背景：
- catalytic activity:Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.,function:Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.,similarity:Belongs to the peptidase C1 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.,
- 功能：
- proteolysis, response to wounding, regulation of cell death, regulation of apoptosis, regulation of programmed cell death,
- 细胞定位：
- Lysosome . Melanosome . Secreted, extracellular space . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity). .
- 组织表达：
- Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum.
- The Human Pro-Cathepsin B ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human Pro-Cathepsin B proteins within the range of 250-16000 pg/ml.
