Human Chitinase 3-Like 1 ELISA Kit
- 货号:KE1209
- 应用:ELISA
- 种属:Human
- 蛋白名称:
- Chitinase-3-like protein 1
- 特异性:
- Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
- 其他名称:
- CHI3L1;Chitinase-3-like protein 1;39 kDa synovial protein;Cartilage glycoprotein 39;CGP-39;GP-39;hCGP-39;YKL-40
- 背景:
- disease:A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:611960]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.,function:Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.,PTM:Glycosylated.,similarity:Belongs to the glycosyl hydrolase 18 family.,subunit:Monomer.,tissue specificity:Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.,
- 功能:
- polysaccharide catabolic process, polysaccharide metabolic process, aminoglycan metabolic process, aminoglycan catabolic process, chitin metabolic process, chitin catabolic process, macromolecule catabolic process, carbohydrate catabolic process,
- 细胞定位:
- Secreted, extracellular space . Cytoplasm . Cytoplasm, perinuclear region . Endoplasmic reticulum .
- 组织表达:
- Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.
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- The Human Chitinase 3-Like 1 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human Chitinase 3-Like 1 proteins within the range of 32-2000 pg/ml.