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Human MIP-1δ ELISA Kit
- 货号:KE1153
- 应用:ELISA
- 种属:Human
- 蛋白名称:
- C-C motif chemokine 15
- 特异性:
- Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
- 其他名称:
- CCL15;MIP5;NCC3;SCYA15;C-C motif chemokine 15;Chemokine CC-2;HCC-2;Leukotactin-1;LKN-1;MIP-1 delta;Macrophage inflammatory protein 5;MIP-5;Mrp-2b;NCC-3;Small-inducible cytokine A15
- 背景:
- function:Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.,function:Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.,online information:CCL14 entry,online information:CCL15 entry,PTM:HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.,PTM:The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood.,similarity:Belongs to the intercrine beta (chemokine CC) family.,subunit:Monomer.,tissue specificity:Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.,tissue specificity:Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients.,
- 功能:
- cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, chemotaxis, immune response, cell-cell signaling, behavior, locomotory behavior, positive regulation of cell proliferation, cellular homeostasis, cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis, regulation of cell proliferation, taxis, homeostatic process, chemical homeostasis, ion homeostasis, metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, calcium ion homeostasis, cation homeostasis, cellular chemical homeostasis,
- 组织表达:
- Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients.
![](/uploadfiles/PIC/ke1153-elisa.jpg)
- The Human MIP-1δ ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human MIP-1δ proteins within the range of 16-1000 pg/ml.