• 基因名称：
• IL23A

• 蛋白名称：
• Interleukin-23 subunit alpha/Interleukin-12 subunit beta

• Human Gene Id：
• 51561

• Human Swiss Prot No：
• Q9NPF7

• Mouse Swiss Prot No：
• Q9EQ14

• 特异性：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• 储存：
• 2-8°C/6 months

• 其他名称：
• IL23A;SGRF;Interleukin-23 subunit alpha;IL-23 subunit alpha;IL-23-A;Interleukin-23 subunit p19;IL-23p19;IL12B;NKSF2;Interleukin-12 subunit beta;IL-12B;Cytotoxic lymphocyte maturation factor 40 kDa subunit;CLMF p40;IL-12 subunit

• 检测方法：
• Colorimetric

• 背景：
• developmental stage:Expressed by newborns dendritic cells.,function:Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.,induction:Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors.,similarity:Belongs to the IL-6 superfamily.,subcellular location:Secreted upon association with IL12B.,subunit:Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.,tissue specificity:Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).,

• 功能：
• cell activation, defense response, inflammatory response, immune response, cell proliferation, response to wounding,response to virus, mononuclear cell proliferation, T cell proliferation, T cell activation, innate immune response,leukocyte activation, lymphocyte activation, lymphocyte proliferation, tissue remodeling, leukocyte proliferation,

• 细胞定位：
• Secreted . Secreted upon association with IL12B.

• 组织表达：
• Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).

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