• 基因名称：
• MIA2

• 蛋白名称：
• Melanoma inhibitory activity protein 2

• Human Gene Id：
• 117153

• Human Swiss Prot No：
• Q96PC5

• Mouse Swiss Prot No：
• Q91ZV0

• 特异性：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• 储存：
• 2-8°C/6 months

• 其他名称：
• MIA2;Melanoma inhibitory activity protein 2

• 检测方法：
• Colorimetric

• 背景：
• disease:Autoantigen found several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL). Isoform 5A and isoform 5B are recognized by patients' sera with tumor specimen of various origins.,disease:Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL). Also found in colorectal and breast carcinomas, head and neck squamous cell carcinomas and melanoma.,function:Tumor-associated antigen.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the cTAGE family.,tissue specificity:At the protein level, isoform 5A is expressed only in testis. Other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. Isoform 5A (at the protein level) and isoform 5B are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 5B, but not isoform 5A, is expressed in head and neck squamous cell carcinoma.,tissue specificity:Expressed in testis, placenta and skin. Expressed at lower level in mammary gland and stomach.,

• 细胞定位：
• Endoplasmic reticulum membrane ; Single-pass membrane protein . Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). .

• 组织表达：
• Highly expressed in liver and weakly in testis. Expression was higher in patients with severe fibrosis or inflammation and chronic hepatitis (PubMed:12586826). Isoform 1 is specifically expressed in lung, testis, small intestine, colon, pancreas, kidney, liver and prostate (PubMed:27138255). Isoform 8 is expressed only in testis (at the protein level). Isoform 8 (at protein level) and isoform 9 are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 9, but not isoform 5A, is expressed in head and neck squamous cell carcinoma (PubMed:12839582).

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