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Total 4E-BP1 Cell-Based Colorimetric ELISA Kit

其他名称：
Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)

背景：
function:Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.,PTM:Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the eIF4E-binding protein family.,subunit:Nonphosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs.,

功能：
regulation of translation, regulation of translational initiation, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, insulin receptor signaling pathway, response to endogenous stimulus, response to hormone stimulus, negative regulation of biosynthetic process, response to organic substance, negative regulation of macromolecule biosynthetic process,negative regulation of macromolecule metabolic process, posttranscriptional regulation of gene expression, negative regulation of translation, negative regulation of cellular biosynthetic process, negative regulation of protein complex assembly, regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process,response to insulin stimulus, cellular response to insulin stimulus, cellular re