p57kip2 (ABT214) IHC kit

    • 货号:IHCM6996
    • 应用:IHC
    • 种属:Human;Mouse;Rat;
      • 靶点:
      • p57
      • 简介:
      • >>Cell cycle
      • 基因名称:
      • CDKN1C KIP2
      • 蛋白名称:
      • Beckwith Wiedemann syndrome;BWCR;BWS;CDKI;CDKN 1C;CDKN1C;CDN1C_HUMAN;Cyclin dependent kinase inhibitor 1C;Cyclin dependent kinase inhibitor p57;Cyclin-dependent kinase inhibitor 1C;Cyclin-dependent ki
      • Human Swiss Prot No:
      • P49918
      • Mouse Swiss Prot No:
      • P49919
      • 免疫原:
      • Synthesized peptide derived from human p57kip2 AA range: 200-316
      • 特异性:
      • The antibody can specifically recognize human p57kip2 protein.
      • 来源:
      • Mouse, Monoclonal/IgG2b, kappa
      • 纯化工艺:
      • The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
      • 储存:
      • 2°C to 8°C/1 year
      • 其他名称:
      • Beckwith Wiedemann syndrome;BWCR;BWS;CDKI;CDKN 1C;CDKN1C;CDN1C_HUMAN;Cyclin dependent kinase inhibitor 1C;Cyclin dependent kinase inhibitor p57;Cyclin-dependent kinase inhibitor 1C;Cyclin-dependent kinase inhibitor p57;KIP 2;KIP2;p57;p57 Kip 2;p57KIP2;WBS
      • 背景:
      • This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010],
      • 功能:
      • disease:Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.,disease:Defects in CDKN1C are involved in tumor formation.,function:Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.,similarity:Belongs to the CDI family.,tissue specificity:Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels ar
      • 细胞定位:
      • Nuclear
      • 组织表达:
      • Placenta/ Kindey
      • 产品图片
      • Human placenta tissue was stained with Anti-p57kip2 (ABT214) Antibody
      • Human placenta tissue was stained with Anti-p57kip2 (ABT214) Antibody