• 靶点：
• MUC6

• 基因名称：
• MUC6

• 蛋白名称：
• MUC6

• Human Gene Id：
• 4588

• Human Swiss Prot No：
• Q6W4X9

• 免疫原：
• Synthesized peptide derived from human MUC6 AA range: 1000-1100

• 特异性：
• The antibody can specifically recognize human MUC6 protein.

• 来源：
• Mouse, Monoclonal/IgG1, kappa

• 纯化工艺：
• The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

• 储存：
• 2°C to 8°C/1 year

• 其他名称：
• Mucin-6 (MUC-6;Gastric mucin-6)

• 背景：
• The MUC6 gene encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial cytoprotection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract (summary by Toribara et al., 1993 [PubMed 7680650]).[supplied by OMIM, Dec 2010],

• 功能：
• developmental stage:Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation.,function:May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Play an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.,induction:Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription factors.,polymorphism:The number of repeats is

• 细胞定位：
• Cytoplasmic

• 组织表达：
• Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.

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