• 靶点：
• CD3E

• 简介：
• >>Hematopoietic cell lineage;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>T cell receptor signaling pathway;>>Chagas disease;>>Measles;>>Human T-cell leukemia virus 1 infection;>>Epstein-Barr virus infection;>>Human immunodeficiency virus 1 infection;>>PD-L1 expression and PD-1 checkpoint pathway in cancer;>>Primary immunodeficiency

• 基因名称：
• CD3E T3E

• 蛋白名称：
• CD3, CD3E

• Human Gene Id：
• 916

• Human Swiss Prot No：
• P07766

• 免疫原：
• Synthesized peptide derived from human CD3, CD3E AA range: 1-100

• 特异性：
• The antibody can specifically recognize human CD3e protein, and shows no reaction with CD3d or CD3g.

• 来源：
• Mouse, Monoclonal/IgG2a, kappa

• 纯化工艺：
• The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

• 储存：
• 2°C to 8°C/1 year

• 其他名称：
• T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain;CD antigen CD3e)

• 背景：
• The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008],

• 功能：
• function:The CD3 complex mediates signal transduction.,online information:CD3E mutation db,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,similarity:Contains 1 ITAM domain.,subunit:The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.,

• 细胞定位：
• Membranous

• 组织表达：
• Membranous

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