• 靶点：
• CD141

• 简介：
• >>Complement and coagulation cascades;>>AGE-RAGE signaling pathway in diabetic complications;>>Fluid shear stress and atherosclerosis

• 基因名称：
• THBD THRM

• 蛋白名称：
• CD141

• Human Gene Id：
• 7056

• Human Swiss Prot No：
• P07204

• 免疫原：
• Synthesized peptide derived from human CD141 AA range: 50-150

• 特异性：
• The antibody can specifically recognize human CD141 protein.

• 来源：
• Mouse, Monoclonal/IgG2b, kappa

• 纯化工艺：
• The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

• 储存：
• 2°C to 8°C/1 year

• 其他名称：
• Thrombomodulin (TM;Fetomodulin;CD antigen CD141)

• 背景：
• The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THR-THBDD) [MIM:188040]. THR-THBDD is a hemostatic disorder characterized by a tendency to thrombosis.,function:Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.,online information:Thrombomodulin,online information:Thrombomodulin entry,PTM:N-glycosylated.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 6 EGF-like domains.,tissue specific

• 细胞定位：
• Membranous

• 组织表达：
• Endothelial cells are unique in synthesizing thrombomodulin.

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