S100A6 (ABT-S100A6) IHC kit
- 货号：IHCM6668
- 应用：IHC
- 种属：Human;
- 免疫原：
- Synthesized peptide derived from human S100A6 AA range: 50-90
- 特异性：
- The antibody can specifically recognize human S100A6 protein.
- 来源：
- Mouse, Monoclonal/IgG1, kappa
- 纯化工艺：
- The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
- 背景：
- S100 calcium binding protein A6(S100A6) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq, Jul 2008],
- 功能：
- induction:Preferentially expressed when quiescent fibroblasts are stimulated to proliferate. It is inducible by growth factors and overexpressed in acute myeloid leukemias.,miscellaneous:This protein co-purified with the prolactin receptor.,PTM:The N-terminus is blocked.,similarity:Belongs to the S-100 family.,similarity:Contains 2 EF-hand domains.,subunit:Homodimer, antiparallel. Interacts with SUGT1.,
- 细胞定位：
- Nuclear, Cytoplasmic
- 组织表达：
- Brain,Fibroblast,Placenta,Platelet,
- Human malignant melanoma tissue was stained with Anti-S100A6 (ABT-S100A6) Antibody
- Human prostate tissue was stained with Anti-S100A6 (ABT-S100A6) Antibody
- Human renal clear cell carcinoma tissue was stained with Anti-S100A6 (ABT-S100A6) Antibody
- Human serous papillary adenocarcinoma of ovary tissue was stained with Anti-S100A6 (ABT-S100A6) Antibody
- Human testis tissue was stained with Anti-S100A6 (ABT-S100A6) Antibody
