Annexin A1 (PT1761) IHC kit
- 货号:IHCM6608
- 应用:IHC
- 种属:Human;Mouse;Rat;
- 蛋白名称:
- Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35)
- 免疫原:
- Synthesized peptide derived from human Annexin A1 AA range: 250-346
- 特异性:
- This antibody detects endogenous levels of Annexin A1 protein.
- 来源:
- Mouse, Monoclonal/IgG1, kappa
- 纯化工艺:
- The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
- 背景:
- This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014],
- 功能:
- domain:A pair of annexin repeats may form one binding site for calcium and phospholipid.,function:Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.,PTM:Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity.,similarity:Belongs to the annexin family.,similarity:Contains 1 annexin repeat.,similarity:Contains 2 annexin repeats.,similarity:Contains 4 annexin repeats.,subcellular location:Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages.,subunit:Homodimer in placenta (20%); linked by transglutamylat
- 细胞定位:
- Cytoplasmic, Nuclear
- 组织表达:
- Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver.
![](/uploadfiles/PIC/pt1761_tonsil.jpg)
- Immunohistochemical analysis of paraffin-embedded Tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, TRIS-EDTA of pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
![](/uploadfiles/PIC/30-ihc2022.jpg)
- Immunohistochemical analysis of paraffin-embedded human tonsil Antibody was diluted at 1:200(4° overnight).
![](/uploadfiles/PIC/PT1761-esophagus.jpg)
- Human esophagus tissue was stained with Anti-Annexin A1 (PT1761) Antibody
![](/uploadfiles/PIC/PT1761-placenta.jpg)
- Human placenta tissue was stained with Anti-Annexin A1 (PT1761) Antibody