CD38 (ABT-CD38) IHC kit

    • 货号:IHCM6572
    • 应用:IHC
    • 种属:Human;
      • 靶点:
      • CD38
      • 简介:
      • >>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Calcium signaling pathway;>>Hematopoietic cell lineage;>>Oxytocin signaling pathway;>>Salivary secretion;>>Pancreatic secretion
      • 基因名称:
      • CD38
      • 蛋白名称:
      • ADP-ribosyl cyclase 1 (EC 3.2.2.5) (Cyclic ADP-ribose hydrolase 1) (cADPr hydrolase 1) (T10) (CD antigen CD38)
      • Human Gene Id:
      • 952
      • Human Swiss Prot No:
      • P28907
      • 免疫原:
      • Synthesized peptide derived from human CD38 AA range: 200-300
      • 特异性:
      • The antibody can specifically recognize human CD38 protein.
      • 来源:
      • Mouse, Monoclonal/IgG1, kappa
      • 纯化工艺:
      • The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
      • 储存:
      • 2°C to 8°C/1 year
      • 背景:
      • The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
      • 功能:
      • catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,developmental stage:Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.,enzyme regulation:ATP inhibits the hydrolyzing activity.,function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.,online information:CD38 entry,similarity:Belongs to the ADP-ribosyl cyclase family.,tissue specificity:Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.,
      • 细胞定位:
      • Membranous
      • 组织表达:
      • Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
      • 产品图片
      • Human tonsil tissue was stained with Anti-CD38 (ABT-CD38) Antibody