• 靶点：
• CEA

• 基因名称：
• CEACAM5 CEA

• 蛋白名称：
• Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e)

• Human Gene Id：
• 1048

• Human Swiss Prot No：
• P06731

• 免疫原：
• Recombiant protein AA range: 35-314

• 特异性：
• This antibody detects endogenous levels of CEA protein.

• 来源：
• Mouse, Monoclonal/IgG2b, kappa

• 纯化工艺：
• The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

• 储存：
• 2°C to 8°C/1 year

• 其他名称：
• Carcinoembryonic antigen antibody;Carcinoembryonic antigen-related cell adhesion molecule 5 antibody;CD66e antibody;CEA antibody;Ceacam5 antibody;CEAM5_HUMAN antibody;DKFZp781M2392 antibody;Meconium antigen 100 antibody;OTTHUMP00000199032 antibody;OTTHUMP00000199033 antibody;OTTHUMP00000199034 antibody;

• 背景：
• This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015],

• 功能：
• function:Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.,PTM:Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.,similarity:Belongs to the immunoglobulin superfamily. CEA family.,similarity:Contains 7 Ig-like (immunoglobulin-like) domains.,subunit:Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.,tissue specificity:Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.,

• 细胞定位：
• Cytoplasmic, Membranous

• 组织表达：
• Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

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