• 靶点：
• Glial Fibrillary Acidic Protein

• 简介：
• >>JAK-STAT signaling pathway

• 基因名称：
• GFAP

• 蛋白名称：
• wu:fb34h11;ALXDRD;cb345;etID36982.3;FLJ42474;FLJ45472;GFAP;GFAP_HUMAN;gfapl;Glial fibrillary acidic protein;Intermediate filament protein;wu:fk42c12;xx:af506734;zgc:110485

• Human Swiss Prot No：
• P14136

• Mouse Swiss Prot No：
• P03995

• Rat Swiss Prot No：
• P47819

• 免疫原：
• Synthesized peptide derived from human Glial Fibrillary Acidic Protein AA range: 300-432

• 特异性：
• The antibody can specifically recognize human GFAP protein.

• 来源：
• Mouse, Monoclonal/IgG1, kappa

• 纯化工艺：
• The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

• 储存：
• 2°C to 8°C/1 year

• 其他名称：
• wu:fb34h11;ALXDRD;cb345;etID36982.3;FLJ42474;FLJ45472;GFAP;GFAP_HUMAN;gfapl;Glial fibrillary acidic protein;Intermediate filament protein;wu:fk42c12;xx:af506734;zgc:110485

• 背景：
• This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008],

• 功能：
• alternative products:Isoforms differ in the C-terminal region which is encoded by alternative exons,disease:Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.,function:GFAP, a class-III intermediate filament, is a cell-spe

• 细胞定位：
• Cytoplasmic

• 组织表达：
• Brain/ Colon

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