Synthesized peptide derived from human FBXW5 AA range: 319-369

This antibody detects endogenous levels of FBXW5 at Human/Mouse/Rat

FBXW5 FBW5 PP3971

FBXW5

F-box/WD repeat-containing protein 5 ;
F-box and WD-40 domain-containing protein 5 ;

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008],

Function:Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.,similarity:Contains 1 F-box domain.,similarity:Contains 3 WD repeats.,subunit:Interacts with SKP1A and CUL1.,

Cytoplasm .

Brain,Cervix,Colon,Ovary,Placenta,Skin,Testis,